Research & Development: Canadian Burden of Skin Disease from 1990 to 2017
Abstract Background: Skin diseases can have high morbidity that can be costly to society and individuals. To date, there has been no comprehensive assessment of the burden of skin disease in Canada. Objectives: To evaluate the burden of 18 skin and subcutaneous diseases from 1990 to 2017 in Canada using the Global Burden of Disease (GBD) data. […]
研究與開發：人工智能可能有助於預測轉移性黑素瘤患者對免疫檢查站封鎖的反應
Press Release from the American Association for Cancer Research Link to page PHILADELPHIA – A computational method that combines clinicodemographic variables with deep learning of pre-treatment histology images could predict response to immune checkpoint blockade among patients with advanced melanoma, according to results published in Clinical Cancer Research, a journal of the American Association for Cancer […]
研究與開發：老年人皮膚癌的流行是老年腫瘤學中的一個新興問題
Abstract Skin cancer is a worldwide, emerging clinical need in the elderly white population, with a steady increase in incidence rates, morbidity and related medical costs. Skin cancer is a heterogeneous group of cancers comprising cutaneous melanoma and non-melanoma skin cancers (NMSC), which predominantly affect elderly patients, aged older than 65 years. Melanoma has distinct […]
研究與開發：溫度依賴性細胞死亡模式
Temperature-dependent cell death patterns induced by functionalized gold nanoparticle photothermal therapy in melanoma cells Abstract Photothermal therapy (PTT) is a promising approach for cancer targeting therapy. However, the temperature-dependent killing of tumor cells in PTT remains unclear. In this study, we report necroptosis plays a role in the anti-tumor effects observed in gold nanorod (GNR)-mediated […]
研究與開發：靶向基因沉默BRAF
Targeted-gene silencing of BRAF to interrupt BRAF/MEK/ERK pathway synergized photothermal therapeutics for melanoma using a novel FA-GNR-siBRAF nanosystem Abstract Melanoma is significantly associated with mutant BRAF gene, a suitable target for siRNA-based anti-melanoma therapy. However, a tumor-specific delivery system is a major hurdle for clinical applications. Here, we developed a novel nano-carrier, FA-GNR-siBRAF for safe […]
