Research & Development: Canadian Burden of Skin Disease from 1990 to 2017

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Abstract Background: Skin diseases can have high morbidity that can be costly to society and individuals. To date, there has been no comprehensive assessment of the burden of skin disease in Canada. Objectives: To evaluate the burden of 18 skin and subcutaneous diseases from 1990 to 2017 in Canada using the Global Burden of Disease (GBD) data. […]

Research & Development: Artificial Intelligence May Help Predict Response to Immune Checkpoint Blockade in Patients With Metastatic Melanoma

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Press Release from the American Association for Cancer Research   Link to page  PHILADELPHIA – A computational method that combines clinicodemographic variables with deep learning of pre-treatment histology images could predict response to immune checkpoint blockade among patients with advanced melanoma, according to results published in Clinical Cancer Research, a journal of the American Association for Cancer […]

Research & Development: Temperature-dependent Cell Death Patterns

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Temperature-dependent cell death patterns induced by functionalized gold nanoparticle photothermal therapy in melanoma cells Abstract Photothermal therapy (PTT) is a promising approach for cancer targeting therapy. However, the temperature-dependent killing of tumor cells in PTT remains unclear. In this study, we report necroptosis plays a role in the anti-tumor effects observed in gold nanorod (GNR)-mediated […]

Research & Development: Targeted-gene Silencing BRAF

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Targeted-gene silencing of BRAF to interrupt BRAF/MEK/ERK pathway synergized photothermal therapeutics for melanoma using a novel FA-GNR-siBRAF nanosystem Abstract Melanoma is significantly associated with mutant BRAF gene, a suitable target for siRNA-based anti-melanoma therapy. However, a tumor-specific delivery system is a major hurdle for clinical applications. Here, we developed a novel nano-carrier, FA-GNR-siBRAF for safe […]