{"id":237468,"date":"2021-01-08T10:23:31","date_gmt":"2021-01-08T10:23:31","guid":{"rendered":"https:\/\/getskinhelp.com\/?p=237468"},"modified":"2022-02-25T18:58:22","modified_gmt":"2022-02-25T18:58:22","slug":"ai-may-help-predict-response-to-immune-checkpoint","status":"publish","type":"post","link":"https:\/\/getskinhelp.com\/ch\/ai-may-help-predict-response-to-immune-checkpoint\/","title":{"rendered":"\u7814\u7a76\u8207\u958b\u767c\uff1a\u4eba\u5de5\u667a\u80fd\u53ef\u80fd\u6709\u52a9\u65bc\u9810\u6e2c\u8f49\u79fb\u6027\u9ed1\u7d20\u7624\u60a3\u8005\u5c0d\u514d\u75ab\u6aa2\u67e5\u7ad9\u5c01\u9396\u7684\u53cd\u61c9"},"content":{"rendered":"<p><strong>\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\u7684\u65b0\u805e\u7a3f&nbsp;&nbsp;<\/strong><\/p>\n\n\n\n<p><a href=\"https:\/\/www.aacr.org\/about-the-aacr\/newsroom\/news-releases\/artificial-intelligence-may-help-predict-response-to-immune-checkpoint-blockade-in-patients-with-metastatic-melanoma\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u93c8\u63a5\u5230\u9801\u9762&nbsp;<\/a><\/p>\n\n\n\n<p>\u8cbb\u57ce-\u6839\u64da\u767c\u8868\u5728\u300a\u91ab\u5b78\u300b\u96dc\u8a8c\u4e0a\u7684\u7d50\u679c\uff0c\u4e00\u7a2e\u7d50\u5408\u81e8\u5e8a\u8166\u96fb\u5716\u8b8a\u91cf\u548c\u6df1\u5ea6\u5b78\u7fd2\u6cbb\u7642\u524d\u7d44\u7e54\u5b78\u5716\u50cf\u7684\u8a08\u7b97\u65b9\u6cd5\uff0c\u53ef\u4ee5\u9810\u6e2c\u665a\u671f\u9ed1\u7d20\u7624\u60a3\u8005\u5c0d\u514d\u75ab\u6aa2\u67e5\u9ede\u963b\u6eef\u7684\u53cd\u61c9\u3002&nbsp;<a href=\"https:\/\/clincancerres.aacrjournals.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u81e8\u5e8a\u764c\u75c7\u7814\u7a76<\/a>\uff0c\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\u96dc\u8a8c\u3002&nbsp;<\/p>\n\n\n\n<p>\u201c\u96d6\u7136\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u88fd\u5291\u5df2\u6df1\u523b\u6539\u8b8a\u4e86\u6cbb\u7642\u65b9\u6cd5\uff0c&nbsp;<a href=\"https:\/\/getskinhelp.com\/ch\/the-1-2-3s-and-a-b-cs-of-skin-cancer\/\">\u9ed1\u8272\u7d20\u7624<\/a>\uff0c\u8a31\u591a\u816b\u7624\u5c0d\u6cbb\u7642\u7121\u53cd\u61c9\uff0c\u8a31\u591a\u60a3\u8005\u7d93\u6b77\u8207\u6cbb\u7642\u6709\u95dc\u7684\u6bd2\u6027\u53cd\u61c9\u3002\u201d\u76f8\u61c9\u7684\u7814\u7a76\u4f5c\u8005\u8aaa&nbsp;<a href=\"https:\/\/med.nyu.edu\/faculty\/iman-osman\" target=\"_blank\" rel=\"noreferrer noopener\">\u4f0a\u66fc\u00b7\u5967\u65af\u66fc\uff08MD\uff09<\/a>\u662f\u7d10\u7d04\u5927\u5b78\u683c\u7f85\u65af\u66fc\u91ab\u5b78\u9662\u76ae\u819a\u75c5\u548c\u91ab\u5b78\u7cfb\uff08\u816b\u7624\u5b78\uff09\u7684\u91ab\u5b78\u816b\u7624\u5b78\u5bb6\uff0c\u7d10\u7d04\u5927\u5b78\u6717\u683c\u8afe\u5927\u5b78Perlmutter\u764c\u75c7\u4e2d\u5fc3\u8de8\u5b78\u79d1\u9ed1\u7d20\u7624\u8a08\u5283\u7684\u8ca0\u8cac\u4eba\u3002 \u201c\u672a\u6eff\u8db3\u7684\u9700\u6c42\u662f\u80fd\u5920\u6e96\u78ba\u9810\u6e2c\u54ea\u4e9b\u816b\u7624\u6703\u5c0d\u54ea\u7a2e\u7642\u6cd5\u7522\u751f\u53cd\u61c9\u7684\u80fd\u529b\u3002\u9019\u5c07\u5be6\u73fe\u500b\u6027\u5316\u7684\u6cbb\u7642\u7b56\u7565\uff0c\u5f9e\u800c\u6700\u5927\u7a0b\u5ea6\u5730\u767c\u63ee\u6f5b\u5728\u7684\u81e8\u5e8a\u76ca\u8655\uff0c\u4e26\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u5c11\u4e0d\u5fc5\u8981\u7684\u6bd2\u6027\u66b4\u9732\u3002\u201d&nbsp;<\/p>\n\n\n\n<p>\u76f8\u61c9\u7684\u7814\u7a76\u4f5c\u8005\u8aaa\uff1a\u201c\u6700\u8fd1\u5e7e\u6b21\u5617\u8a66\u9810\u6e2c\u514d\u75ab\u7642\u6cd5\u53cd\u61c9\u7684\u65b9\u6cd5\u90fd\u5177\u6709\u5f88\u5f37\u7684\u6e96\u78ba\u6027\uff0c\u4f46\u662f\u4f7f\u7528\u4e86\u4e0d\u6613\u63a8\u5ee3\u5230\u81e8\u5e8a\u7684RNA\u6e2c\u5e8f\u7b49\u6280\u8853\u3002\u201d&nbsp;<a href=\"https:\/\/med.nyu.edu\/faculty\/aristotelis-tsirigos\" target=\"_blank\" rel=\"noreferrer noopener\">Aristotelis Tsirigos\u535a\u58eb<\/a>\uff0c\u7d10\u7d04\u5927\u5b78\u683c\u7f85\u65af\u66fc\u91ab\u5b78\u9662\u8a08\u7b97\u91ab\u5b78\u7814\u7a76\u6240\u6559\u6388\uff0c\u7d10\u7d04\u5927\u5b78\u6717\u683c\u8afe\u5927\u5b78Perlmutter\u764c\u75c7\u4e2d\u5fc3\u6210\u54e1\u3002 \u201c\u6211\u5011\u7684\u65b9\u6cd5\u8868\u660e\uff0c\u53ef\u4ee5\u4f7f\u7528\u8b77\u7406\u6a19\u6e96\u7684\u81e8\u5e8a\u4fe1\u606f\uff08\u4f8b\u5982\u6cbb\u7642\u524d\u7684\u7d44\u7e54\u5b78\u5716\u50cf\u548c\u5176\u4ed6\u81e8\u5e8a\u8b8a\u91cf\uff09\u4f86\u9810\u6e2c\u53cd\u61c9\u3002\u201d&nbsp;<\/p>\n\n\n\n<p>\u7814\u7a76\u4eba\u54e1\u4f7f\u7528\u4e86\u4f86\u81ea2004\u5e74\u81f32018\u5e74\u9593\u63a5\u53d7\u514d\u75ab\u6aa2\u67e5\u9ede\u5c01\u9396\u6cbb\u7642\u7684121\u4f8b\u8f49\u79fb\u6027\u9ed1\u7d20\u7624\u60a3\u8005\u7684\u8a13\u7df4\u968a\u5217\u4e2d\u7684\u6578\u64da\u3002\u6240\u6709\u60a3\u8005\u5747\u63a5\u53d7\u4e00\u7dda\u6297CTLA-4\u6cbb\u7642\uff0c\u6297PD-1\u6cbb\u7642\u6216\u806f\u5408\u6cbb\u7642\u5169\u8005\u7684\u81e8\u5e8a\u7d50\u679c\u5747\u8a18\u9304\u70ba\u75be\u75c5\u6216\u53cd\u61c9\u7684\u9032\u5c55\uff0c\u5305\u62ec\u5b8c\u5168\u6216\u90e8\u5206\u53cd\u61c9\uff08\u672c\u539f\u7406\u9a57\u8b49\u7814\u7a76\u6392\u9664\u4e86\u75be\u75c5\u7a69\u5b9a\u7684\u60a3\u8005\uff09\u3002\u7814\u7a76\u4eba\u54e1\u4f7f\u7528\u4e86\u7a31\u70ba\u6df1\u5ea6\u5377\u7a4d\u795e\u7d93\u7db2\u7d61\uff08DCCN\uff09\u7684\u8a08\u7b97\u6a5f\u7b97\u6cd5\u4f86\u5206\u6790\u9ed1\u8272\u7d20\u7624\u8f49\u79fb\u6027\u816b\u7624\u7684\u6578\u5b57\u5716\u50cf\uff0c\u4e26\u78ba\u5b9a\u8207\u6cbb\u7642\u53cd\u61c9\u76f8\u95dc\u7684\u6a21\u5f0f\u3002\u901a\u904e\u9019\u7a2e\u65b9\u6cd5\uff0c\u4ed6\u5011\u958b\u767c\u4e86\u4e00\u7a2e\u53cd\u61c9\u5206\u985e\u5668\uff0c\u65e8\u5728\u9810\u6e2c\u60a3\u8005\u672a\u7d93\u6cbb\u7642\u7684\u816b\u7624\u662f\u5426\u6703\u5c0d\u514d\u75ab\u6aa2\u67e5\u9ede\u963b\u6eef\u6216\u6cbb\u7642\u5f8c\u7684\u9032\u5c55\u7522\u751f\u53cd\u61c9\u3002\u8a72DCCN\u53cd\u61c9\u5206\u985e\u5668\u5df2\u57282010\u5e74\u81f32017\u5e74\u9593\u5728\u8303\u5fb7\u6bd4\u723e\u7279-\u82f1\u683c\u62c9\u59c6\u764c\u75c7\u4e2d\u5fc3\u63a5\u53d7\u6cbb\u7642\u768430\u4f8b\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u7368\u7acb\u968a\u5217\u4e2d\u9032\u884c\u4e86\u9a57\u8b49\u3002&nbsp;<\/p>\n\n\n\n<p>DCCN\u97ff\u61c9\u5206\u985e\u5668\u7684\u6027\u80fd\u901a\u904e\u8a08\u7b97\u66f2\u7dda\u4e0b\u7684\u9762\u7a4d\uff08AUC\uff09\u4f86\u8a55\u4f30\uff0c\u66f2\u7dda\u7684\u9762\u7a4d\u662f\u6a21\u578b\u6e96\u78ba\u6027\u7684\u5ea6\u91cf\uff0c\u5f97\u5206\u70ba1\u8868\u793a\u5b8c\u7f8e\u9810\u6e2c\u3002\u5728\u57f9\u8a13\u548c\u9a57\u8b49\u968a\u5217\u4e2d\uff0cDCCN\u9810\u6e2c\u6a21\u578b\u7684AUC\u5747\u7d04\u70ba0.7\u3002&nbsp;<\/p>\n\n\n\n<p>\u70ba\u4e86\u63d0\u9ad8\u6a21\u578b\u7684\u9810\u6e2c\u6e96\u78ba\u6027\uff0c\u7814\u7a76\u4eba\u54e1\u9032\u884c\u4e86\u591a\u8b8a\u91cf\u908f\u8f2f\u56de\u6b78\uff0c\u5c07DCCN\u9810\u6e2c\u8207\u5e38\u898f\u81e8\u5e8a\u7279\u5fb5\u76f8\u7d50\u5408\u3002\u6700\u7d42\u6a21\u578b\u7d0d\u5165\u4e86DCCN\u9810\u6e2c\uff0c\u6771\u90e8\u5408\u4f5c\u816b\u7624\u5c0f\u7d44\uff08ECOG\uff09\u7684\u8868\u73fe\u72c0\u614b\u548c\u6cbb\u7642\u65b9\u6848\uff08\u6297CTLA-4\u55ae\u4e00\u7642\u6cd5\uff0c\u6297PD-1\u55ae\u4e00\u7642\u6cd5\u6216\u806f\u5408\u7642\u6cd5\uff09\u3002\u5728\u8a13\u7df4\u548c\u9a57\u8b49\u968a\u5217\u4e2d\uff0c\u591a\u8b8a\u91cf\u5206\u985e\u5668\u7684AUC\u5747\u7d04\u70ba0.8\u3002\u5728\u9a57\u8b49\u968a\u5217\u4e2d\uff0c\u5206\u985e\u5668\u53ef\u4ee5\u5c07\u60a3\u8005\u5206\u70ba\u75be\u75c5\u9032\u5c55\u7684\u9ad8\u98a8\u96aa\u548c\u4f4e\u98a8\u96aa\uff0c\u5169\u7d44\u4e4b\u9593\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\u5dee\u7570\u986f\u8457\u3002&nbsp;<\/p>\n\n\n\n<p>\u96d6\u7136\u8a13\u7df4\u968a\u5217\u4e2d\u7684\u5927\u591a\u6578\u60a3\u8005\u63a5\u53d7\u6297CTLA-4\u55ae\u85e5\u6cbb\u7642\uff08\u7d04\u4f54\u60a3\u8005\u768464\uff05\uff09\uff0c\u4f46\u9a57\u8b49\u968a\u5217\u4e2d\u7684\u5927\u591a\u6578\u60a3\u8005\u63a5\u53d7\u4e86\u6297PD-1\u85e5\u7269\uff08\u7d04\u4f54\u60a3\u8005\u768453\uff05\uff09\u3002\u5967\u65af\u66fc\u6307\u51fa\uff0c\u7d50\u679c\u8868\u660e\u67d0\u4e9b\u9810\u6e2c\u6a21\u5f0f\u4e26\u975e\u91dd\u5c0d\u514d\u75ab\u6aa2\u67e5\u9ede\u9776\u6a19\u3002\u985e\u6fc0\u6d3b\u6620\u5c04\u53ef\u4ee5\u8b58\u5225\u795e\u7d93\u7db2\u7d61\u7528\u4f86\u751f\u6210\u9810\u6e2c\u7684\u6578\u5b57\u5716\u50cf\u4e2d\u7684\u5340\u57df\uff0c\u9019\u8868\u660e\u7d30\u80de\u6838\u5c0d\u65bcDCCN\u9810\u6e2c\u5f88\u91cd\u8981\uff0cDCCN\u9810\u6e2c\u4e2d\u8d8a\u4f86\u8d8a\u5927\u7684\u6838\u8207\u75be\u75c5\u9032\u5c55\u76f8\u95dc\u3002\u5979\u88dc\u5145\u8aaa\uff1a\u201c\u9019\u4e9b\u7d50\u679c\u8868\u660e\u500d\u6027\u53ef\u80fd\u662fDCCN\u6aa2\u6e2c\u5230\u7684\u751f\u7269\u5b78\u6c7a\u5b9a\u56e0\u7d20\u4e4b\u4e00\u3002\u201d&nbsp;<\/p>\n\n\n\n<p>\u201cThere is potential for using computer algorithms to analyze histology images and predict treatment response, but more work needs to be done using larger training and testing datasets, along with additional validation parameters, in order to determine whether an algorithm can be developed that achieves clinical-grade performance and is broadly generalizable,\u201d&nbsp;Tsirigos&nbsp;said.&nbsp;<\/p>\n\n\n\n<p>Limitations of the study include the relatively small number of images used to train the computer algorithm, which included 302 images in the training cohort and 40 images in the validation cohort. \u201cThere is data to suggest that thousands of images might be needed to train models that achieve clinical-grade performance,\u201d said&nbsp;Tsirigos.&nbsp;<\/p>\n\n\n\n<p>\u9019\u9805\u7814\u7a76\u7531\u7d10\u7d04\u5927\u5b78\u9ed1\u8272\u7d20\u7624\u5c08\u696d\u7814\u7a76\u5353\u8d8a\u8a08\u5283\uff08SPORE\uff09\u8d08\u6b3e\uff0c\u9ed1\u8272\u7d20\u7624\u7814\u7a76\u806f\u76df\uff0c\u7f8e\u570b\u764c\u75c7\u5354\u6703\uff0c\u52de\u62c9\u548c\u827e\u85a9\u514b\u00b7\u73c0\u723e\u59c6\u7279\u7279\u764c\u75c7\u4e2d\u5fc3\u4ee5\u53caOnassis\u57fa\u91d1\u6703\u8d0a\u52a9\u3002&nbsp;<\/p>\n\n\n\n<p>Osman and&nbsp;Tsirigos&nbsp;declare no conflicts of interest.<\/p>","protected":false},"excerpt":{"rendered":"<p>Press Release from the American Association for Cancer Research&nbsp;&nbsp; Link to page&nbsp; PHILADELPHIA \u2013 A computational method that combines clinicodemographic variables with deep learning of pre-treatment histology images could predict response to immune checkpoint blockade among patients with advanced melanoma, according to results published in&nbsp;Clinical Cancer Research, a journal of the American Association for Cancer [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":237204,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[7,46],"tags":[116,50,115,117,56,58,57],"class_list":["post-237468","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","category-support","tag-american-cancer-society","tag-artificial-intelligence","tag-melanoma-research-alliance","tag-metastatic-melanoma","tag-rd","tag-research","tag-skin-disease"],"_links":{"self":[{"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/posts\/237468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/comments?post=237468"}],"version-history":[{"count":8,"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/posts\/237468\/revisions"}],"predecessor-version":[{"id":241827,"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/posts\/237468\/revisions\/241827"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/media\/237204"}],"wp:attachment":[{"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/media?parent=237468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/categories?post=237468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/getskinhelp.com\/ch\/wp-json\/wp\/v2\/tags?post=237468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}